Piperine is an organic chemical compound found in black pepper. It is located in the outer layer of the fruit of black pepper. It is a colorless crystalline substance, which can be also found in a cream yellow colour.

The published research results indicate that piperine can block the formation of new fat cells and reduce the level of fat in the bloodstream. This is the result of blocking the activity of genes that control the formation of new fat cells. Piperine also increases the secretation of digestive juices and enhances digestion of food. It also affects the absorption of nutrients like vitamin C, selenium, beta-carotene, vitamin A, vitamin B6 and coenzyme Q.

Another effect of piperine is the stimulation and proliferation of melanocyte in cell structures. After the use of piperine and ultraviolet light therapy, the skin becomes much darker. 

Another beneficial health effect of piperine is inhibiting chemical substances responsible for mutations of the genetic material of cells. In vitro studies in cells of mice and rats indicate that administration of piperine can inhibit tumor growth.

Piperine has also antidepressant effects due to the increase of serotonin and dopamine neurotransmission. People with depression show a deficit of these substances.

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